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Molecular mechanisms and therapeutic strategies of vulnerable atherosclerotic plaques
Wen-Qiang CHEN MD, Yun ZHANG MD, PhD, FACC,
Frontiers of Medicine 2010, Volume 4, Issue 1, Pages 36-42 doi: 10.1007/s11684-010-0020-y
Keywords： vulnerable plaque animal models mechani-sm detection treatment
p-Cresyl sulfate promotes the formation of atherosclerotic lesions and induces plaque instability by
Hui Han,Yanjia Chen,Zhengbin Zhu,Xiuxiu Su,Jingwei Ni,Run Du,Ruiyan Zhang,Wei Jin
Frontiers of Medicine 2016, Volume 10, Issue 3, Pages 320-329 doi: 10.1007/s11684-016-0463-x
Coronary atherosclerosis is a major complication of chronic kidney disease. This condition contributes to the increased mortality in dialysis patients. p-Cresyl sulfate (PCS) is a prototype of protein-bound uremic toxins that cannot be efficiently removed through routine dialysis procedures. In the present study, ApoE−/− mice that underwent 5/6 nephrectomy were randomly divided into two groups, namely, vehicle-treated group (n = 20) and PCS-treated group (n = 20). Mice were sacrificed for en face and immunohistological analyses after 8 or 24 weeks of high-fat diet. Rat aortic vascular smooth muscle cells (VSMCs) were treated with phosphate buffer solution or 500 µmol/L PCS for in vitro evaluation. PCS-treated mice were observed to suffer increased atherosclerotic lesions after eight weeks of PCS administration. Moreover, 24 weeks of PCS administration also markedly increased the vulnerability index of aortic plaques. PCS was also observed to facilitate the migration and proliferation of VSMCs during the progression of the disease. Moreover, PCS disturbed the balance between matrix metalloproteinases and tissue inhibitor of metalloproteinases within the plaques. Thus, PCS played a vital role in promoting atherogenesis and disturbing the stability of formed plaques probably by targeting VSMCs.
Keywords： p-cresyl sulfate atherosclerosis plaque stability vascular smooth muscle cell
Xin Zou, Ke Chen, Jiawei Zou, Peiyi Han, Jie Hao, Zeguang Han
Frontiers of Medicine Pages 185-192 doi: 10.1007/s11684-020-0754-0
Keywords： 2019-nCoV ACE2 single-cell RNA-seq
The main and added effects of heat on mortality in 33 Chinese cities from 2007 to 2013
Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 7, doi: 10.1007/s11783-023-1681-5
● The main and added effect from heat co-existed in China.
Keywords： Heat Main effect Added effect Mortality Vulnerable population
Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis
Namita Gupta,N.D. Gupta,Akash Gupta,Saif Khan,Neha Bansal
Frontiers of Medicine 2015, Volume 9, Issue 1, Pages 72-76 doi: 10.1007/s11684-014-0347-x
Keywords： metalloproteinase-8 chronic periodontitis pocket probing depth clinical attachment level gingival index plaque
Degradable Plastics Are Vulnerable to Cracks Letter
Xuxu Yang, Jason Steck, Jiawei Yang, Yecheng Wang, Zhigang Suo
Engineering 2021, Volume 7, Issue 5, Pages 624-629 doi: 10.1016/j.eng.2021.02.009
A plastic may degrade in response to a trigger. The kinetics of degradation have long been characterized by the loss of weight and strength over time. These methods of gross characterization, however, are misleading when plastic degrades heterogeneously. Here, we study heterogeneous degradation in an extreme form: the growth of a crack under the combined action of chemistry and mechanics. An applied load opens the crack, exposes the crack front to chemical attack, and causes the crack to outrun gross degradation. We studied the crack growth in polylactic acid (PLA), a polyester in which ester bonds break by hydrolysis. We cut a crack in a PLA film using scissors, tore it using an apparatus, and recorded the crack growth using a camera through a microscope. In our testing range, the crack velocity was insensitive to load but was sensitive to humidity and pH. These findings will aid the development of degradable plastics for healthcare and sustainability.
Keywords： Degradation Plastics Hydrolysis pH Cracking
Polar Offshore Engineering Equipment: Development Status and Key Technologies
Shi Guijie , Feng Jiaguo, Kang Meize, Zhang Zhengyi, Liu Yuan
Strategic Study of CAE 2021, Volume 23, Issue 3, Pages 144-152 doi: 10.15302/J-SSCAE-2021.03.021
Polar offshore engineering equipment provides a major platform and symbolizes the strength of China to participate in Arctic offshore oil and gas development. Currently, the design, construction, and support capacities of China’s polar offshore engineering equipment are not internationally recognized, which does not match with the large shipbuilding sector of China. In this article, we analyze the development demand for polar offshore engineering equipment in China, present the application status of these equipment, investigate the key technologies, and summarize the existing problems regarding these equipment in China. Furthermore, we propose the establishment of a research and application innovation project of common key technologies for Arctic offshore oil and gas exploration and development, an international research and development center for polar offshore oil and gas engineering technologies, and a China–Russia Arctic energy joint venture company. This study centers on the coordination of the Arctic development and environmental protection capabilities, and aims to provide a reference for developing the polar offshore engineering equipment in China and provide guidance for China’s participation in Arctic oil and gas development.
Keywords： Arctic oil and gas，low temperature sea ice，vulnerable ecology，offshore engineering equipment
Environmental Data Acquisition, Elaboration and Integration: Preliminary Application to a Vulnerable Article
Massimiliano Lega,Marco Casazza,Laura Turconi,Fabio Luino,Domenico Tropeano,Gabriele Savio,Sergio Ulgiati,Theodore Endreny
Engineering 2018, Volume 4, Issue 5, Pages 635-642 doi: 10.1016/j.eng.2018.08.011
Climate conditions play a crucial role in the survival of mountain communities, whose survival already critically depends on socioeconomic factors. In the case of montane areas that are prone to natural hazards, such as alpine slope failure and debris flows, climatic factors exert a major influence that should be considered when creating appropriate sustainable scenarios. In fact, it has been shown that climate change alters the availability of ecosystem services (ES), thus increasing the risks of declining soil fertility and reduced water availability, as well as the loss of grassland, potential shifts in regulatory services (e.g., protection from natural hazards), and cultural services. This study offers a preliminary discussion on a case study of a region in the Italian Alps that is experiencing increased extreme precipitation and erosion, and where an isolated and historically resilient community directly depends on a natural resource economy. Preliminary results show that economic factors have influenced past population trends of the Novalesa community in the Piemonte Region in northwest Italy. However, the increasing number of rock fall and debris flow events, which are triggered by meteo-climatic factors, may further influence the livelihood and wellbeing of this community, and of other similar communities around the world. Therefore, environmental monitoring and data analysis will be important means of detecting trends in landscape and climate change and choosing appropriate planning options. Such analysis, in turn, would ensure the survival of about 10% of the global population, and would also represent a possibility for future economic development in critical areas prone to poverty conditions.
Keywords： Environmental data elaboration Climate change Mountain community Italy Resilience Socioecological system Hydrogeological risk
Title Author Date Type Operation
Molecular mechanisms and therapeutic strategies of vulnerable atherosclerotic plaques
Wen-Qiang CHEN MD, Yun ZHANG MD, PhD, FACC,
Journal Article
p-Cresyl sulfate promotes the formation of atherosclerotic lesions and induces plaque instability by
Hui Han,Yanjia Chen,Zhengbin Zhu,Xiuxiu Su,Jingwei Ni,Run Du,Ruiyan Zhang,Wei Jin
Journal Article
data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable
Xin Zou, Ke Chen, Jiawei Zou, Peiyi Han, Jie Hao, Zeguang Han
Journal Article
The main and added effects of heat on mortality in 33 Chinese cities from 2007 to 2013
Journal Article
Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis
Namita Gupta,N.D. Gupta,Akash Gupta,Saif Khan,Neha Bansal
Journal Article
Degradable Plastics Are Vulnerable to Cracks
Xuxu Yang, Jason Steck, Jiawei Yang, Yecheng Wang, Zhigang Suo
Journal Article
Polar Offshore Engineering Equipment: Development Status and Key Technologies
Shi Guijie , Feng Jiaguo, Kang Meize, Zhang Zhengyi, Liu Yuan
Journal Article
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